Osmotic fragility test in heterozygotes for alpha and beta thalassaemia.

Effectiveness of one tube osmotic fragility screening in detecting beta-thalassaemia trait.

The effectiveness of the one tube method of osmotic fragility with three buffered solutions (0.32% saline, 0.36% saline, and tyrode) as a screening test for beta-thalassaemia trait was evaluated in several groups of subjects from Greece, Yugoslavia, and Thailand. The results clearly demonstrated that 0.36% saline is the most sensitive and effective solution since it could detect 96 to 100% of h...

Iron state in alpha and beta thalassaemia trait.

The iron state was examined in two groups of pregnant women who were carriers of alpha and beta thalassaemia genes. In both groups the haematological expression of the disease--namely, haemoglobin and mean cell haemoglobin concentrations--was nearly identical. In patients with alpha thalassaemia the ferritin concentrations and percentage of ferritin deficiency was the same as in normal pregnant...

III RESULTS OF TESTS FOR HAEMOLYSIS AND FOR OSMOTIC FRAGILITY OF RED BLOOD CELLS Osmotic Fragility

SYNOPSIS Nineteen patients with morphological abnormalities of the red blood cells are described, and these formed approximately 3 % of the total cases of cardiac valvular disease. In two patients the abnormal blood film developed after the insertion of an aortic and mitral valve prosthesis respectively, but in another two patients the abnormal blood film was corrected by aortic valve surgery. ...

Single Tube Osmotic Fragility Test: a Sensitive and Specific Test for Screening of Microcytosis

Aim and Objective: To evaluate usefulness of Single Tube Osmotic Fragility Test (SOFT) for detection of microcytosis and its further application for thalassemia trait screening. Background: Iron deficiency and thalassemia are common causes of microcytic anaemia in Pakistan. Easy microcytosis screening is necessary at a low resourced country like Pakistan, so that further investigations speciall...

Screening for beta thalassaemia